The Actin Cytoskeleton

✍ Scribed by Brigitte M. Jockusch (eds.)

• Publisher: Springer International Publishing
• Year: 2017
• Tongue: English
• Leaves: 356
• Series: Handbook of Experimental Pharmacology 235
• Edition: 1
• Category: Library

✦ Synopsis

Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

✦ Table of Contents

Front Matter....Pages i-xii
Mammalian Actins: Isoform-Specific Functions and Diseases....Pages 1-37
Assembly and Maintenance of Myofibrils in Striated Muscle....Pages 39-75
Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions....Pages 77-122
Actin Filament Structures in Migrating Cells....Pages 123-152
Signalling Pathways Controlling Cellular Actin Organization....Pages 153-178
ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins....Pages 179-206
Common Themes in Cytoskeletal Remodeling by Intracellular Bacterial Effectors....Pages 207-235
Viruses That Exploit Actin-Based Motility for Their Replication and Spread....Pages 237-261
Multiscale View of Cytoskeletal Mechanoregulation of Cell and Tissue Polarity....Pages 263-284
Molecular Control of Actin Dynamics In Vivo: Insights from Drosophila ....Pages 285-310
From Cytoskeleton to Gene Expression: Actin in the Nucleus....Pages 311-329
What We Know and Do Not Know About Actin....Pages 331-347
Back Matter....Pages 349-351

✦ Subjects

Pharmacology/Toxicology;Cell Physiology