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The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C

โœ Scribed by Goldschmidt-Clermont, P.; Machesky, L.; Baldassare, J.; Pollard, T.


Book ID
121432000
Publisher
American Association for the Advancement of Science
Year
1990
Tongue
English
Weight
1013 KB
Volume
247
Category
Article
ISSN
0036-8075

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A key event in signal transduction in many eukaryotes is activation of polyphosphoinositideโ€specific phospholipase C (PIC). This enzyme hydrolyses the plasma membraneโ€associated lipid, phosphatidylinositol(4,5)bisphosphate (Ptdlns(4,5)P~2~) which leads to the production of the two second messenger m