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The absorption, metabolism and excretion of dimethyl sulfoxide by Rhesus monkeys

✍ Scribed by Don L. Layman; Stanley W. Jacob


Book ID
118340911
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
393 KB
Volume
37
Category
Article
ISSN
0024-3205

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35S-Furosemide was administered to beagle dogs and rhesus monkeys in an oral solution on a single and a 20 repeated 5-mg/kg/day dosing regimen. Following the single dose, 25.0% (dogs) and 24.0% (monkeys) of the dose were excreted in the urine in 24 hr. TLC analysis demonstrated that both species had