The absolute configuration of a new amino­alkyl­phenol derived from (R)-(–)-2-phenyl­glycine

✍ Scribed by Zhang, Guang-You ;Wang, Xiang-Bo ;Zhao, Jin-Yan ;Wang, Wan-Hui ;Yang, Xiao-Feng

• Book ID: 104486886
• Publisher: International Union of Crystallography
• Year: 2006
• Tongue: English
• Weight: 268 KB
• Volume: 62
• Category: Article
• ISSN: 1600-5368
• DOI: 10.1107/s1600536806022963

✦ Synopsis

The chiral aminoalkylphenol N-[(S)-1-(5-methyl-2-hydroxyphenyl)ethyl]-N–[(R)-2-hydroxy-1-phenylethyl]amine, C~17~H~21~NO~2~, was synthesized starting from R-(-)-2-phenylglycine. The corresponding hydrochloride salt was prepared and crystallized as an ethyl acetate solvate, affording N-[(R)-2-hydroxy-1-phenylethyl]-N-[(S)-1-(5-methyl-2-hydroxyphenyl)ethyl]aminium chloride ethyl acetate solvate, C~17~H~22~NO~2~
^+^·Cl^−^·C~4~H~8~O~2~, and the absolute configuration of the new stereogenic centre determined, from which that of the chiral aminoalkylphenol was inferred. The dihedral angle between the two aromatic rings is 40.74 (11)°.