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The absence of stereoselective P-glycoprotein- and multidrug resistance-associated protein-mediated transport of daunorubicin

✍ Scribed by Chatchanok Loetchutinat; Christine Heywang; Waldemar Priebe; Arlette Garnier-Suillerot

Book ID
113992733
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
370 KB
Volume
62
Category
Article
ISSN
0006-2952

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The multidrug-resistance (MR) status of camptothecin (CPT) was investigated in colon adenocarcinoma HT29 cells, leukemia K562, and breast carcinoma MCF7 cells expressing P-glycoprotein (Pgp) and/or MR-associated protein (MRP1). The concentration that induced 50% growth inhibition (IC(50)) against CP