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The absence of an apolipoprotein ϵ4 allele is associated with a more aggressive form of Alzheimer's disease

✍ Scribed by Dr Yaakov Stern; Jason Brandt; Marilyn Albert; Diane M. Jacobs; Xinhua Liu; Karen Bell; Karen Marder; Mary Sano; Steven Albert; Caridad Del-Castillo Castenada; Fred Bylsma; Ben Tycko; Richard Mayeux


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
581 KB
Volume
41
Category
Article
ISSN
0364-5134

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The apolipoprotein E ε2 allele is associ
✍ Cornelia M. van Duijn; Peter de Knijff; Anita Wehnert; Joke De Voecht; Juliana B 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 652 KB

It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b