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The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake

✍ Scribed by Samlee Mankhetkorn; Arlette Garnier-Suillerot


Book ID
119414360
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
198 KB
Volume
343
Category
Article
ISSN
0014-2999

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra