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The ability of prostate-specific antigen (PSA) density to predict an upgrade in Gleason score between initial prostate biopsy and prostatectomy diminishes with increasing tumour grade due to reduced PSA secretion per unit tumour volume

✍ Scribed by Niall M. Corcoran; Rowan G. Casey; Matthew K.H. Hong; John Pedersen; Stephen Connolly; Justin Peters; Laurence Harewood; Martin E. Gleave; Anthony J. Costello; Chris M. Hovens; S. Larry Goldenberg

Book ID: 115199331
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 183 KB
Volume: 110
Category: Article
ISSN: 1464-4096
DOI: 10.1111/j.1464-410x.2011.10681.x

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The ability of prostate-specific antigen

The ability of prostate-specific antigen (PSA) density to predict an upgrade in Gleason score between initial prostate biopsy and prostatectomy diminishes with increasing tumour grade due to reduced PSA secretion per unit tumour volume

✍ Niall M. Corcoran; Rowan G. Casey; Matthew K.H. Hong; John Pedersen; Stephen Con 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB

Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b **What's known on the subject? and What does the study add?** Due to sampling error, the Gleason score of clinically localized prostate cancer is frequently underestimated at the time of initial biopsy. Given that this may lead to