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The ability of gallate and pyrogallol moieties of catechins to inhibit P-glycoprotein function

✍ Scribed by Narumi Sugihara; Yuusuke Tsutsui; Tomohiko Tagashira; Tominari Choshi; Satoshi Hibino; Jun Kamishikiryou; Koji Furuno


Book ID
119296321
Publisher
Elsevier
Year
2011
Tongue
English
Weight
397 KB
Volume
3
Category
Article
ISSN
1756-4646

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P-glycoprotein (P-gp), a multidrug resistance (MDR) protein encoded by the MDR1 gene in humans, is responsible for the efflux of structurally diverse drugs. Previous studies in our laboratory have shown that excipients such as poly(ethylene)glycol (PEG)-300, Cremophor EL, and Tween 80 inhibit P-gp a