A comparison of commonly used polyethoxy
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Erin D. Hugger; Barbara L. Novak; Philip S. Burton; Kenneth L. Audus; Ronald T.
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Article
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2002
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John Wiley and Sons
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English
β 276 KB
P-glycoprotein (P-gp), a multidrug resistance (MDR) protein encoded by the MDR1 gene in humans, is responsible for the efflux of structurally diverse drugs. Previous studies in our laboratory have shown that excipients such as poly(ethylene)glycol (PEG)-300, Cremophor EL, and Tween 80 inhibit P-gp a