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The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis

✍ Scribed by H. G. Koch, P. Nabel, R. Junker, K. Auberger, R. Schobess…


Book ID
120907828
Publisher
Springer
Year
1999
Tongue
English
Weight
79 KB
Volume
158
Category
Article
ISSN
0340-6997

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A common haplotype for the 677T thermola
✍ M. Linnebank; A. Homberger; U. Nowak-Göttl; H. G. Koch 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 18 KB

The common polymorphic transition 677C>T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene causes a thermolabile enzyme variant. This variant is associated with moderate hyperhomocysteinemia, a risk factor for vascular disease and thrombophilia. Up to now, it remained unclear if the therm