The 5′ region of the tryptophan hydroxylase gene: mutation search and association study with alcoholism
✍ Scribed by H. Ishiguro; T. Saito; H. Shibuya; M. Toru; T. Arinami
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 77 KB
- Volume
- 106
- Category
- Article
- ISSN
- 1435-1463
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Tyrosine hydroxylase is the rate-limiting step in the biosynthesis of catecholamines. To find variants in the tyrosine hydroxylase (TH) gene that are associated with schizophrenia, mood disorders, or alcohol dependence, all of the exons, the exon-intron boundaries, and the 5 promoter region of the T
Tyrosine hydroxylase (TH) gene is the ratelimiting enzyme in the synthesis of catecholamines. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia, affective disorders, and Parkinsonism. This study examined a possible associat
## Abstract We investigated the association between two markers in the seventh intron of the tryptophan hydroxylase gene (__TPH__ C218A and C779A) in a population‐based case control study of 780 genotyped subjects. As in prior studies, the two markers were in strong linkage disequilibrium. The phen