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The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep

✍ Scribed by William M Abraham; Ashfaq Ahmed; Alejandro Cortes; Marek W Sielczak; Wendy Hinz; Jennifer Bouska; Carmine Lanni; Randy L Bell


Book ID
115888112
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
820 KB
Volume
217
Category
Article
ISSN
0014-2999

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πŸ“œ SIMILAR VOLUMES


A bradykinin-antagonist blocks antigen-i
✍ M. SolΓ¨r; M. Sielczak; W.M. Abraham πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier 🌐 English βš– 689 KB

The effects of a new bradykinin-antagonist, NPC-567 (D-Arg [hydroxyproline3, D-phenylalanine7] bradykinin) were studied on antigen-induced airway hyperresponsiveness and inflammation in allergic sheep (n = 7). Specific lung resistance (sRL) was used to assess airway responses to inhaled Ascaris suum

The 5-Lipoxygenase Inhibitory Activity o
✍ P.E. Malo; R.L. Bell; T.K. Shaughnessy; J.B. Summers; D.W. Brooks; G.W. Carter πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier 🌐 English βš– 417 KB

Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in the metabolic pathway of arachidonic acid leading to the leukotrienes is 5-lipoxygenase (5-LO). A selective and potent 5-LO inhibitor, zileu