The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep
β Scribed by William M Abraham; Ashfaq Ahmed; Alejandro Cortes; Marek W Sielczak; Wendy Hinz; Jennifer Bouska; Carmine Lanni; Randy L Bell
- Book ID
- 115888112
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 820 KB
- Volume
- 217
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The effects of a new bradykinin-antagonist, NPC-567 (D-Arg [hydroxyproline3, D-phenylalanine7] bradykinin) were studied on antigen-induced airway hyperresponsiveness and inflammation in allergic sheep (n = 7). Specific lung resistance (sRL) was used to assess airway responses to inhaled Ascaris suum
Leukotrienes are biologically active lipid mediators capable of producing airway inflammation, hyperresponsiveness and bronchoconstriction. The first enzyme in the metabolic pathway of arachidonic acid leading to the leukotrienes is 5-lipoxygenase (5-LO). A selective and potent 5-LO inhibitor, zileu