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The 5-HT7 receptor as a mediator and modulator of antidepressant-like behavior

✍ Scribed by Gor Sarkisyan; Amanda J. Roberts; Peter B. Hedlund

Book ID
116285741
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
867 KB
Volume
209
Category
Article
ISSN
0166-4328

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## Abstract We have studied the effects of 5‐HT~1A~ and 5‐HT~7~ serotonin receptor activation in hippocampal CA3‐CA1 synaptic transmission using patch clamp on mouse brain slices. Application of either 5‐HT or 8‐OH DPAT, a mixed 5‐HT~1A~/5‐HT~7~ receptor agonist, inhibited AMPA receptor‐mediated ex