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The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor

✍ Scribed by Olivier Blondel; Monique Gastineau; Michel Langlois; Rodolphe Fischmeister


Book ID
110003926
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
227 KB
Volume
125
Category
Article
ISSN
0007-1188

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Comparative 5-HT4 receptor antagonist ac
✍ Marlene L. Cohen; William Bloomquist; David Calligaro; Steven Swanson πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 148 KB

LY353433 is a selective, potent, and orally active 5-HT 4 receptor antagonist with a long duration of pharmacological activity following its oral administration to rats. After oral administration of LY353433 (100 mg/kg) to rats, peak plasma concentration of the parent material was approximately 25 n