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The 5′ end of theKCNQ1OT1gene is hypomethylated in the Beckwith-Wiedemann syndrome

✍ Scribed by Flavia Cerrato; Maria Vernucci; Paolo V. Pedone; Lorenzo Chiariotti; Gianfranco Sebastio; Carmelo B. Bruni; Andrea Riccio


Publisher
Springer
Year
2002
Tongue
English
Weight
146 KB
Volume
111
Category
Article
ISSN
0340-6717

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The Beckwith-Wiedemann syndrome (BWS) is an overgrowth malformation syndrome that occurs with an incidence of 1:13,700 births. There is a striking incidence of childhood tumors found in BWS patients. Various lines of investigation have localized "imprinted" genes involved in BWS and associated child