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The 3-Hydroxypiperidine Skeleton: Key Element in Natural Product Synthesis

โœ Scribed by Marloes A. Wijdeven; Jorgen Willemsen; Floris P. J. T. Rutjes


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
519 KB
Volume
2010
Category
Article
ISSN
1434-193X

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First Desymmetrization of a Centrosymmet
โœ Joanne M. Holland; Mark Lewis; Adam Nelson ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 88 KB

Exploitation of molecular symmetry can greatly improve the efficiency of syntheses. The symmetry embedded in the centrosymmetric AB dioxepane fragment of hemibrevetoxin B was exploited for the first time in the preparation of an established intermediate in its total synthesis. Desymmetrization of th