The 2G Single Nucleotide Polymorphism (SNP) in the MMP-1 Promoter Contributes to High Levels of MMP-1 Transcription in MCF-7/ADR Breast Cancer Cells

High levels of MMP-1 expression in the a

High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells

✍ Ulrike Benbow; Grant B. Tower; Colby A. Wyatt; Giovanna Buttice; Constance E. Br 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB 👁 2 views

Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymo