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The 1.5 Å Crystal Structure of a Prokaryote Serpin: Controlling Conformational Change in a Heated Environment

✍ Scribed by James A. Irving; Lisa D. Cabrita; Jamie Rossjohn; Robert N. Pike; Stephen P. Bottomley; James C. Whisstock


Book ID
114329258
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
495 KB
Volume
11
Category
Article
ISSN
0969-2126

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Serpins are members of a family of structurally related protein inhibitors of serine proteinases, with molecular masses between 40 and 100kDa. In contrast to other, simpler, proteinase inhibitors, they may interact with proteinases as inhibitors, as substrates, or as both. They undergo conformationa