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Thapsigargin induces microglial transformation from amoeboid- to ramified- type in vivo

โœ Scribed by R Yagi; S Tanaka; T Koike


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
15 KB
Volume
29
Category
Article
ISSN
0894-1491

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Thapsigargin induces microglial transfor
โœ Ryoji Yagi; Shuuitsu Tanaka; Tatsuro Koike ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 190 KB

Microglia generally display amoeboid morphology under prevalent culture conditions. We found that cultured microglia derived from rat cerebral cortex undergo a morphological transformation from amoeboid to process-bearing microglia upon treatment with thapsigargin (TG), a specific Ca 2ฯฉ -ATPase inhi