Thallium-201 uptake in Langerhans cell histiocytosis of bone
β Scribed by Z. Bar-Sever; L. P. Connolly; D. Jaramillo; S. T. Treves
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 268 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0301-0449
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Background. Because prostaglandin (PG) E2 has been identified in the bone lesions of Langerhans cell histiocytosis (LCH), we speculated that indomethacin, a potent PG inhibitor, may be useful in patients with symptomatic LCH involving the bony skeleton. Procedure. We used indomethacin to treat patie
Langerhans' cell histiocytosis (LCH) is characterized by an accumulation and/or proliferation of cells with a Langerhans' cell (LC) phenotype. The aetiology and pathogenesis of LCH are unknown; it is suggested that LCH is caused by an immunological dysregulation. Production of cytokines is a central