Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
β Scribed by Roland S. Liblau; Steven M. Singer; Hugh O. McDevitt
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 837 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-5699
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Mechanisms controlling the Th1/Th2 phenotype of a primary immune response are often discussed assuming that the generation of Th1 and Th2 cells from the common CD4 + precursor T helper (pTh) involves an interaction of this pTh cell with an antigen-presenting cell (APC) in the form of a two-cell inte
The role of TGF-g 1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-g 1 has a profound inhibitory effect on naive CD4 + T cell undergoing