Th 1-type immunity is incompatible with successful pregnancy

✍ Scribed by Raj Raghupathy

• Book ID: 104298709
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 458 KB
• Volume: 18
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(97)01127-4

✦ Synopsis

Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th1-type immunity may help resolve 'unexplained' pregnancy failure.