TGFβ Type III and TGFβ Type II receptors have distinct activities during epithelial–mesenchymal cell transformation in the embryonic heart

Epithelial-mesenchymal transformation in

Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFβ signal transduction mechanisms

✍ Angelique S. Boyer; Christof P. Erickson; Raymond B. Runyan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 502 KB

During early development, progenitors of the heart valves and septa are formed by epithelial-mesenchymal transformation (EMT) of endothelial cells in the atrioventricular (AV) canal. Previously, we showed that pertussis toxin, a specific inhibitor of a subset of G proteins, inhibited EMT in chick AV