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TGFβ MEDIATES THE ACTION OF RETINOIDS AND VITAMIN D3 ON U937 CELLS DIFFERENTIATION

✍ Scribed by COMMES, Thérèse; PIQUEMAL, David; DEFACQUE, Hélène; SEVILLA, Claude; Marti, Jacques


Book ID
122956477
Publisher
Portland Press
Year
1996
Tongue
English
Weight
197 KB
Volume
88
Category
Article
ISSN
0248-4900

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Vitamin D and retinoids cooperate to inhibit the proliferation and induce the differentiation of human myelomonocytic U937 leukemia cells. In the present work, we investigated the role of TGF-␤ as an endogenous mediator of this process. We found that the TGF-␤1 precursor began to accumulate in cell