TGF-βSignaling in Colon Cancer Cells
✍ Scribed by Fazhi Li; Yanna Cao; Courtney M. Townsend; Tien C. Ko
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 195 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0364-2313
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## Abstract Polarized gastrointestinal epithelial cells form tight junctions that spatially separate apical and basolateral cell membrane domains. These domains harbor functionally distinct proteins that contribute to cellular homeostasis and morphogenesis. Transforming growth factor β (TGFβ) is a
Previously, we described a model culture system for comparing responsiveness of poorly differentiated and well-differentiated human colon carcinoma cells to exogenous growth factors. While polypeptide growth stimulators elicited an up-regulation of c-myc, as well as a mitogenic response in the well-