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TGF-β1 selectively supports prostaglandin D2 production in activated human mast cells

✍ Scribed by Gebhardt, T.; Detmer, F.; Lorentz, A.; Sellge, G.; Manns, M.P.; Bischoff, S.C.

Book ID: 119491694
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 129 KB
Volume: 111
Category: Article
ISSN: 1097-6825
DOI: 10.1016/s0091-6749(03)80630-9

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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I