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TGF-β1 Secreted by Hepatocellular Carcinoma Induces the Expression of the Foxp3 Gene and Suppresses Antitumor Immunity in the Tumor Microenvironment

✍ Scribed by Yi Wang, Bin Deng, Wenqing Tang, Taotao Liu, Xizhong Shen

Book ID
120962416
Publisher
Springer US
Year
2013
Tongue
English
Weight
626 KB
Volume
58
Category
Article
ISSN
0163-2116

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## Abstract Bleomycin produces its fibrogenic effect, at least in part, by TGF‐β1 secretion. Treatment of IMR‐90 human embryonic lung fibroblasts with bleomycin at 0.5 μg/ml results in a 1.6‐fold increase of TGF‐β1 as determined by a specific ELISA assay for TGF‐β1 after acidification of the condit