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TGF-β1 induces the expression of α1(I) procollagen mRNA in liver stellate cells by a H202-C/EBPβ-dependent mechanism

✍ Scribed by L. Fontana; A. Auster; E.R. Gaarcia-Treviano; M. Iraburu; M. Roikind


Book ID
117640569
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
100 KB
Volume
16
Category
Article
ISSN
0945-053X

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Oxidative stress plays a key role in liver fibrosis. Both inflammatory cells and activated Kupffer cells produce H 2 O 2 , an oxidant involved in the activation of hepatic stellate cells (HSC). Increased production of reactive oxygen intermediates (ROIs) in fibrotic livers is associated in part with