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TGF-β1 and TGF-β2 strongly enhance the secretion of plasminogen activator inhibitor-1 and matrix metalloproteinase-9 of the human prostate cancer cell line PC-3

✍ Scribed by Lutz Konrad; Jonas A. Scheiber; Lena Schwarz; Andres J. Schrader; Rainer Hofmann


Book ID
116858195
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
509 KB
Volume
155
Category
Article
ISSN
0167-0115

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✍ Volker Ellenrieder; Sandra F. Hendler; Claudia Ruhland; Wolfgang Boeck; Guido Ad 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 216 KB

TGF-beta strongly promotes local tumor progression in advanced epithelial tumors, though the underlying mechanisms are poorly understood. In the present study, we demonstrate the potential of TGF-beta to increase the invasiveness of the pancreatic cancer cell lines PANC-1 and IMIM-PC1. TGF-beta-indu