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TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

✍ Scribed by Christoph Becker; Massimo C. Fantini; Christoph Schramm; Hans A. Lehr; Stefan Wirtz; Alexei Nikolaev; Jürgen Burg; Susanne Strand; Ralf Kiesslich; Samuel Huber; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Peter R. Galle; Manfred Blessing; Stefan Rose-John; Markus F. Neurath


Book ID
116570336
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
749 KB
Volume
21
Category
Article
ISSN
1074-7613

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## Abstract Integrin αυβ6 plays a very important role in the progression of colon cancer cells and is now defined as a novel, independent prognostic indicator for aggressive colon cancer in humans. Herein, we use the RNA interfering technology to downregulate the expression of αυβ6 in colon cancer