TGF-β inhibits the platelet-derived growth factor-induced formation of inositol trisphosphate in MG-63 human osteosarcoma cells

Differential inhibitory effects of TGF-β

Differential inhibitory effects of TGF-β on EGF-, PDGF-, and HBGF-1-stimulated MG63 human osteosarcoma cell growth: Possible involvement of growth factor interactions at the receptor and postreceptor levels

✍ Hiroyuki Mioh; Jan-Kan Chen 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 980 KB

The growth of MG63 human osteosarcoma cell line in 5 % serum is stimulated by epidermal growth factor (EGF), platelet-derived growth factor (PDGF), or heparinbinding growth factor-1 (HBGF-1). The mitogenic effect of EGF and PDGF is completely blocked by TFG-f3 at 1 ng per ml and the effect of HBGF-1