TGF-β induces novel Lef-1 splice variants through a Smad-independent signaling pathway

TGFβ inducible early gene-1 (TIEG1) and

TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

✍ Nalini M. Rajamannan; Malayannan Subramaniam; Theodore P. Abraham; Vlad C. Vasil 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 539 KB

## Abstract Cellular mechanisms causing cardiac hypertrophy are currently under intense investigation. We report a novel finding in the TGFβ inducible early gene (TIEG) null mouse implicating TIEG1 in cardiac hypertrophy. The TIEG^−/−^ knock‐out mouse was studied. Male mice age 4–16 months were cha