TGF-β Enhances Osteoclast Differentiation in Hematopoietic Cell Cultures Stimulated with RANKL and M-CSF

Roles of stromal cell RANKL, OPG, and M-

Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-β regulation of osteoclast differentiation

✍ Mary Karst; Genevieve Gorny; Rachelle J. Sells Galvin; Merry Jo Oursler 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB

## Abstract To better understand the complex roles of transforming growth factor‐beta (TGF‐β) in bone metabolism, we examined the impact of a range of TGF‐β concentrations on osteoclast differentiation. In co‐cultures of support cells and spleen or marrow osteoclast precursors, low TGF‐β concentrat