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TGF-β and TNF-α: antagonistic cytokines controlling type I collagen gene expression

✍ Scribed by Franck Verrecchia; Alain Mauviel

Book ID
113527617
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
235 KB
Volume
16
Category
Article
ISSN
0898-6568

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✍ Kenichi Yamane; Hiroyuki Suzuki; Hironobu Ihn; Mitsuyasu Kato; Hirohide Yoshikaw 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB

## Abstract The α2(I) collagen gene shows cell type‐specific expression, however, the mechanism behind this specificity remains to be determined. We demonstrate here that transforming growth factor‐beta (TGF‐β)‐mediated induction of α2(I) collagen gene is regulated by DNA methylation in a cell type