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TGF-B3 induction of BMSC induces bone formation in vivo

✍ Scribed by Jason T. Rich; Jennifer Bryan; Audrey McAlinden

Book ID
116729756
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
60 KB
Volume
27
Category
Article
ISSN
0945-053X

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In vivo, indomethacin blockade of bone formation has been used to illustrate the role of prostaglandins. Indomethacin blocks the constitutive (COX-1) and inducible (COX-2) forms of cyclo-oxygenase, and is therefore nonspecific in its action. To test the hypothesis that COX-2 mediates the bone format