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TGF-B promotes epithelial-mesenchymal transition and invasiveness via RhoB and MAPK signaling in pancreatic cancer cell lines

✍ Scribed by Wada, Michihiko; Hosotani, Ryo; Imamura, Masayuki; Beauchamp, Robert D.


Book ID
122867027
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
196 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and