Cover......Page 1
Preface......Page 8
PART I - PRINCIPLES OF ANAESTHESIA......Page 14
1. Clinical trials and statistics......Page 16
2. Cellular physiology/pharmacology relevant to anaesthesia......Page 28
3. General principles of pharmacology and pharmacokinetics......Page 36
4. Anatomy of the cardiovascular system......Page 46
5. The heart......Page 57
6. Peripheral circulation and control of cardiac output and arterial pressure......Page 69
7. Drugs acting on the cardiovascular and autonomic nervous systems......Page 80
8. Anatomy of the respiratory tract......Page 116
9. Respiratory physiology......Page 124
10. Drugs acting on the respratory system......Page 134
12. Physiology of the nervous system......Page 151
11. Anatomy of the nervous system......Page 145
13. Inhalation anaesthetic agents......Page 167
14. Intravenous anaesthetic agents......Page 184
15. Local anaesthetic agents......Page 199
16. Sedative and anticonvulsant drugs......Page 207
17. Physiology and measurement of pain......Page 216
18. Analgesic drugs......Page 226
19. Muscle function and neuromuscular blockade......Page 238
20. Gastrointestinal physiology......Page 251
21. Nausea, vomiting and their treatment......Page 259
22. The liver......Page 265
23. Haematology......Page 274
24. Immunology and body defences......Page 285
25. Renal physiology......Page 294
26. Drugs used inrenal disease......Page 304
27 Metabolism, the stress response to surgery and perioperative thermoregulation......Page 312
28. Endocrine function......Page 324
29. Maternal and neonatal physiology......Page 338
30. Basic physics for the anaesthetist......Page 351
31. Clinical measurement......Page 368
32. Anaesthetic apparatus......Page 388
PART II - PRACTICE OF ANAESTHESIA......Page 15
33. The operating theatre environment......Page 424
34. Preoperative assessment and premedication......Page 432
35. Intercurrent disease and anaesthesia......Page 444
36. Preoperative checking of equipment and environment......Page 470
37. The practical conduct of anaesthesia......Page 475
38. Monitoring......Page 485
39. Fluid, electrolyte and acid-base balance......Page 504
40. Complications during anaesthesia......Page 516
41. Postoperative care......Page 539
42. Postoperative pain......Page 559
43. Local anaesthetic techniques......Page 570
44. Anaesthesia for gynaecological and genitourinary surgery......Page 591
45. Anaesthesia for orthopaedic surgery......Page 597
46. Anaesthesia for ENT surgery......Page 605
47. Anaesthesia for ophthalmic surgery......Page 609
48. Anaesthesia for radiology and radiotherapy......Page 621
49. Anaesthesia and psychiatric disease......Page 626
50. Day-case anaesthesia......Page 629
51. Emergency anaesthesia......Page 634
52. Obstetric anaesthesia and analgesia......Page 644
53. Paediatric anaesthesia and intensive care......Page 665
54. Dental anaesthesia......Page 679
55. Anaesthesia for plastic, endocrine and vascular surgery......Page 687
56. Hypotensive anaesthesia......Page 697
57. Neurosurgical anaesthesia......Page 703
58. Anaesthesia for thoracic surgery......Page 714
59. Anaesthesia for cardiac surgery......Page 726
60. The intensive care unit......Page 737
61. Management ofchronic pain......Page 753
62. Cardiopulmonary resuscitation......Page 763
Appendices......Page 774
Appendix la - Abbreviations used in text and appendices......Page 775
Appendix Ib - SI system......Page 779
Appendix II - Inhaled anaesthetic agents - physical properties......Page 781
Appendix III - Cardiovascular system......Page 782
Appendix IVa - Chemical pathology - biochemical values......Page 785
Appendix IVb - Conversion chart - hydrogen ion concentration to pH......Page 787
Appendix V - Haematology......Page 788
Appendix VI - Fluid balance......Page 791
Appendix VII - Renal function tests......Page 793
Appendix VIII - Pulmonary function tests......Page 794
Appendix IX - Paediatrics......Page 797
Appendix X - Gas flows in anaesthetic breathing systems......Page 800
Index......Page 802