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Tetrahydrolipstatin: Thermal and Hydrolytic Degradation

✍ Scribed by Henri Stalder; Pierre R. Schneider; Gottfried Oesterhelt

Publisher
John Wiley and Sons
Year
1990
Tongue
German
Weight
893 KB
Volume
73
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The thermal and hydrolytic degradation of tetrahydrolipstatin (THL, 1) was investigated. All main degradation products were isolated, characterized, and synthesized. Labile intermediates unavailable to isolation were detected and identified by GC/MS analysis of their silylated derivatives, and whenever possible, compared with independently prepared reference compounds. The identified degradation products represent at least 97% of the total degradation mixture. Two main reaction pathways arc proposed. Pharmacological data are reported for the degradation mixture and the main degradation products.

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