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Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats

✍ Scribed by Xi Wang; Yoshiyuki Hattori; Hiroko Satoh; Chigusa Iwata; Nobuyuki Banba; Tsuyoshi Monden; Kohsuke Uchida; Yuichiro Kamikawa; Kikuo Kasai


Book ID
113586548
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
325 KB
Volume
555
Category
Article
ISSN
0014-2999

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In cirrhosis, intrahepatic endothelial dysfunction is one of the mechanisms involved in the increased resistance to portal blood flow and therefore in the development of portal hypertension. Endothelial nitric oxide synthase (eNOS) uncoupling due to deficiency of tetrahydrobiopterin (BH4) results in