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Tetrabenazine therapy of pediatric hyperkinetic movement disorders

✍ Scribed by Samay Jain; Paul E. Greene; Steven J. Frucht

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
78 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Tetrabenazine (TBZ), a presynaptic dopamine depletor and postsynaptic dopamine receptor blocker, is widely used for the treatment of hyperkinetic movement disorders in adults. However, reports of its use in children are limited. We review the efficacy and tolerability of TBZ therapy in 31 children with hyperkinetic movement disorders refractory to other medications. TBZ was effective in reducing the severity of movement disorders resistant to treatment with other medicines. When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug‐induced Parkinsonism. © 2006 Movement Disorder Society

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