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Tests of linkage and heterogeneity in Mendelian diseases using identity by descent scores

✍ Scribed by Dr. Aravinda Chakravarti; Judith A. Badner; Ching Chun Li; D. C. Rao

Book ID
102843694
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
591 KB
Volume
4
Category
Article
ISSN
0741-0395

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✦ Synopsis

When linkage between a recessive Mendelian disease and specific candidate genes is investigated, identity by descent scores in affected sib pairs may be used for tests of linkage and heterogeneity. Statistical tests for performing this analysis are presented. The efficiency and statistical power of the method are also investigated using computer simulations.

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