Tests of association of immunoglobulin allotype genes and viral oncogenesis in chickens

✍ Scribed by Larry D. Bacon; Lean Kuan Ch'ng; John Spencer; Albert A. Benedict; Aly M. Fadly; Richard L. Witter; Lyman B. Crittenden

• Publisher: Springer-Verlag
• Year: 1986
• Tongue: English
• Weight: 735 KB
• Volume: 23
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00373015

✦ Synopsis

Chickens from Regional Poultry Research Laboratory (RPRL) inbred line 63 are resistant to virally-induced Marek's disease (MD) and lymphoid leukosis (LL) and are relatively strong regressors of virally-induced Rous sarcomas. In contrast, RPRL line 100 chickens are highly susceptible to MD and LL and are weaker regressors of Rous sarcomas than line 63. RPRL lines 100 and 63 differ for alleles at the I9G-1 (G-1) allotype locus, but have identical IoM-1 (M-l) allotype alleles. To test the possible association of the G-1 locus with variations in resistance to vitally-induced tumors, homozygous and heterozygous genotypes among F 3 crosses were infected. F 3 chickens with different G-1 types were comparable in their resistance to MD tumors following inoculation with the JM strain of the MD virus, and for their ability to regress Rous sarcoma tumors induced by the Rous sarcoma virus (RSV) RAV-1. However, following RAV-1 virus infection a smaller proportion of G-la/G-1 a F 3 or F 4 birds developed LL tumors than G-U/G-1 e and G-U/G-I e birds. Genes determining immunoglobulin heavy chains were therefore associated with a recessive resistance to B-cell lymphomagenesis in chickens.