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Test–retest reliability of arterial spin labeling with common labeling strategies

✍ Scribed by Yufen Chen; Danny J.J. Wang; John A. Detre

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
727 KB
Volume
33
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To compare the test–retest reproducibility of three variants of arterial spin labeling (ASL): pseudo‐continuous (pCASL), pulsed (PASL) and continuous (CASL).

Materials and Methods

Twelve healthy subjects were scanned on a 3.0T scanner with PASL, CASL, and pCASL. Scans were repeated within‐session, after 1 hour, and after 1 week to assess reproducibility at different scan intervals.

Results

Comparison of within‐subject coefficients of variation (wsCV) demonstrated high within‐session reproducibility (ie, low wsCV) for CASL‐based methods (gray matter [GM] wsCV for pCASL: 3.5% ± 0.02%, CASL: 4.1% ± 0.07%) compared to PASL (wsCV: 7.5% ± 0.06%), due to the higher signal‐to‐noise ratio (SNR) associated with continuous labeling, evident in the 20% gain in temporal SNR and 58% gain in raw SNR for pCASL relative to PASL. At the 1‐week scan interval, comparable reproducibility between PASL (GM wsCV 9.2% ± 0.12%) and pCASL (GM wsCV 8.5% ± 0.14%) was observed, indicating the dominance of physiological fluctuations.

Conclusion

Although all three approaches are capable of measuring cerebral blood flow within a few minutes of scanning, the high precision and SNR of pCASL, with its insensitivity to vessel geometry, make it an appealing method for future ASL application studies. J. Magn. Reson. Imaging 2011;33:940–949. © 2011 Wiley‐Liss, Inc.

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