✦ LIBER ✦

Test–retest reliability of a functional MRI anticipatory anxiety paradigm in healthy volunteers

✍ Scribed by Thérèse Schunck; Gilles Erb; Alexandre Mathis; Nathalie Jacob; Christian Gilles; Izzie Jacques Namer; Dieter Meier; Rémy Luthringer

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 523 KB
Volume: 27
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.21237

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To evaluate the reproducibility of neural activations induced by an anticipatory anxiety provocation challenge in healthy volunteers.

Materials and Methods

Fourteen healthy male volunteers participated in two separate functional MRI (fMRI) sessions in which they underwent a paradigm based on anticipation of aversive transcutaneous electrical nerve stimulations. This paradigm consisted of alternating presentation of red circles associated with the likelihood that aversive stimuli may be given and blue circles during which the subjects knew that no shock could be given. Anxiety state was compared before the fMRI sessions and during the threat periods using clinical scales (Hamilton, STAI‐Y1), the Bond and Lader Visual Analogue Scale, and self‐rating scales of apprehension and stimulus aversivity.

Results

The selected paradigm induced anticipatory anxiety of moderate intensity as suggested by clinical scales and apprehension rating, without any habituation to the somatosensory stimulus across sessions. Compared to rest periods, threat of the aversive stimulus induced clear brain activation in anticipatory anxiety‐related areas: frontal/prefrontal cortex, insula, lentiform nucleus, temporal pole, and cingulate cortex. Anxiety symptoms and cerebral activity were reproducible across sessions.

Conclusion

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