Testosterone: Action - Deficiency - Substitution

✍ Scribed by Focko F. G. Rommerts (auth.), Prof. Dr. med. Eberhard Nieschlag, Priv.-Doz. Dr. med. Hermann M. Behre (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1998
• Tongue: English
• Leaves: 599
• Edition: 2
• Category: Library

✦ Synopsis

New developments in testosterone action and therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in 20 chapters. This 2nd edition has been thoroughly revised and extended. The book presents the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Effects on bones, muscles, lipids, hair, the prostate, and the brain are considered in separate chapters. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. The pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations are discussed in detail, and side effects of testosterone treatment are reviewed. This is the state-of-the-art book about testosterone action and therapy for endocrinologists, andrologists, urologists and pharmacologists.

✦ Table of Contents

Front Matter....Pages I-X
Testosterone: An overview of biosynthesis, transport, metabolism and nongenomic actions....Pages 1-31
The androgen receptor: Physiology and pathophysiology....Pages 33-106
Behavioural correlates of testosterone....Pages 107-142
The role of testosterone in spermatogenesis....Pages 143-168
Androgens and hair....Pages 169-186
Androgens and bone metabolism....Pages 187-207
Androgens and muscles....Pages 209-227
Androgens, cardiovascular risk factors and atherosclerosis....Pages 229-257
Androgens and the prostate....Pages 259-291
Pharmacology and clinical uses of testosterone....Pages 293-328
Comparative pharmacokinetics of testosterone esters....Pages 329-348
Clinical pharmacology of testosterone pellet implants....Pages 349-364
Long-term experience with testosterone replacement through scrotal skin....Pages 365-388
A permeation-enhanced non-scrotal testosterone transdermal system for the treatment of male hypogonadism....Pages 389-422
Percutaneous dihydrotestosterone treatment....Pages 423-436
Androgens in male senescence....Pages 437-471
Androgen therapy in non-gonadal disease....Pages 473-512
Testosterone in male contraception....Pages 513-528
Androgen treatment of female-to-male transsexuals....Pages 529-544
Abuse of androgens and detection of illegal use....Pages 545-565
Back Matter....Pages 567-597

✦ Subjects

Urology/Andrology; Pharmacology/Toxicology; Dermatology; Gynecology