Testing the three-pool white matter model adapted for use with T2 relaxometry
✍ Scribed by Trevor Andrews; Jack L. Lancaster; Stephen J. Dodd; Carmen Contreras-Sesvold; Peter T. Fox
- Book ID
- 102533669
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 88 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A three‐pool model was used to improve white‐matter T~2~ relaxometry in low signal‐to‐noise (SNR) data. To verify the model very high SNR T~2~ relaxometry experiments were performed on myelinated tissue samples and three‐pool fractions were consistently found. Relaxation curves based on the in vitro results were simulated with multiple SNRs and fit using the three‐pool model and three less constraining nonnegative least squares‐based methods. All methods performed well with noiseless data. At lower SNR values the three‐pool model was superior, primarily due to the fact that the other methods often could not unambiguously calculate pool fractions. Magn Reson Med 54:449–454, 2005. © 2005 Wiley‐Liss, Inc.