## Abstract Although quantities derived from solvent accessible surface areas (SASA) are useful in many applications in protein design and structural biology, the computational cost of accurate SASA calculation makes SASA‐based scores difficult to integrate into commonly used protein design methodo
✦ LIBER ✦
Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design
✍ Scribed by Marcel Schmidt am Busch; Anne Lopes; Najette Amara; Christine Bathelt; Thomas Simonson
- Book ID
- 115001222
- Publisher
- BioMed Central
- Year
- 2008
- Tongue
- English
- Weight
- 536 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1471-2105
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## Abstract Solvent effects play a crucial role in mediating the interactions between proteins and their ligands. Implicit solvent models offer some advantages for modeling these interactions, but they have not been parameterized on such complex problems, and therefore, it is not clear how reliable
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