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Testing the amyloid cascade hypothesis in a novel mouse model of Alzheimer's disease that shows complete disease progression

โœ Scribed by Carol A. Colton; Michael P. Vitek; Donna Wilcock


Book ID
118465263
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
164 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). This study evaluated a novel ฮผMRI strategy based on โ€œpassive stainingโ€ of brain samples by gadoteric acid. The protocol was tested at 4.7T on control animals and APP/PS1 mice modeling AD lesions. T~1~ was strongly dec