Testing of sunset yellow and orange II for genotoxicity in different laboratory animal species
✍ Scribed by J. Wever; R. Münzner; H. W. Renner
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 431 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
✦ Synopsis
The azo dyes Sunset Yellow and Orange II were gavaged to rodent species to check bile, urine, and fecal extracts for possible mutagenic activity in the Ames test or in bone marrow cells for clastogenicity using cytogenetic test systems. After oral application the dyes showed a negative response in bile, excrements, and bone marrow.
When an exogenous metabolic activation was performed, increased revertant numbers using Salmonella strain TAlOO were obtained only in fecal extracts of Sunset Yellow-treated animals.
It is concluded that no genotoxic harm is to be expected from the ingestion of Sunset Yellow or Orange (I.