Testing mouse mammary tumor virus superantigen as adjuvant in cytotoxic T-lymphocyte responses against a melanoma tumor antigen

✍ Scribed by Susanne Wirth; Frédéric Bille; Sylvain Koenig; Nathalie Wehrli; Isabelle Miconnet; Frédéric Lévy; Heidi Diggelmann; Pedro Romero; Hans Acha-Orbea

• Book ID: 102272221
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: French
• Weight: 133 KB
• Volume: 99
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.10237

✦ Synopsis

Abstract

Cytotoxic T cells represent a powerful strategy for antitumor treatment. Depending on the route of injection, an important role for CD4 T cell–mediated help was observed in the induction of this response. For this reason, we investigated whether induction of a CTL response to the HLA‐A2–restricted immunodominant peptide melanoma antigen Melan‐A was improved by using rVVs expressing the CTL‐defined epitope alone or in combination with an SAg. In the latter case, the few infected dendritic cells simultaneously presented an SAg and an antigen, i.e., peptide. Here, we show that the anti‐Melan‐A response was efficiently induced but not significantly improved by coexpression of the SAg. © 2002 Wiley‐Liss, Inc.